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Acute Lymphoblastic Leukemia in Adolescents & Young Adults. • Prednisone: 1260 mg/m2 (FRALLE) vs 840 mg/m2. – Increased methotrexate doses in patients <45y.blood versus synovium. prednisone (n=7; range 2–20mg/day), methotrexate (n=11) alone or combined with cyclosporin (n=1) or anti-TNF treatment (n=1), and.

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